NASHVILLE, Tenn. -- An unnecessary roughness penalty for a blindside hit wiped out Marcus Mariotas interception. The Titans quarterback managed to fall on the ball after simply dropping it on handoff.His third mistake counted and couldnt have been more costly Sunday.Mariota fumbled when sacked, and Robert Mathis picked up the ball and ran 14 yards for the clinching touchdown in a 34-26 loss to the Indianapolis Colts . This latest loss leaves the 2014 Heisman Trophy winner and No. 2 overall pick in the 2015 NFL draft just 2-8 on his home field for his career with his latest turnover bringing that total to 19: six fumbles and 13 interceptions.Tennessee coach Mike Mularkey said the key is protecting the ball better.Thats one of the things we have to stop doing, Mularkey said.The Titans (3-4) trailed 27-23 when they got the ball at their own 25 with 1:55 left and a timeout. A perfect moment for Mariota to follow up his winning performance of a week ago against Cleveland.On the first play, T.Y. McGill came through the Titans line where Brian Schwenke replaced starting left guard Quinton Spain, who was carted off the field in the second quarter. McGill stripped Mariota of the ball , which Mathis grabbed for the easy TD with 1:47 left.I was trying to step up in the pocket and make a throw to the left, Mariota said. They moved from the pressure, probably could have moved away from it. It was one of those things that was kind of perfect timing for him. I was separating my hands to throw the football. He just kind of poked at it and ended up knocking it out.Josh McNarys hit on Titans tight end Delanie Walker wiped out Patrick Robinsons interception late in the third quarter, and Mariota later dropped the ball in the same drive for a 9-yard loss to end the quarter. But Mariota capped the drive with a TD pass.Mariota finished throwing for 232 yards and two touchdowns. But the Titans quarterback was streaky, opening the game completing his first five passes with the last a 10-yard TD pass to left tackle Taylor Lewan. Then he missed five of his next six passes, throwing too high. He sailed a pass to Andre Johnson on third-and-1 in the second quarter.The quarterback took the blame, noting he also missed Rishard Matthews on a deep pass down the field.Again, that really was on me, Mariota said. I mean I just missed throws in the pass game, especially on third down. We cant be missing those opportunities. Weve got to continue to move the chains, allow us to either score points or pin them deep.Mariota completed passes to seven different receivers counting Lewan.Tight end Delanie Walker, who caught a 7-yard TD pass that tied the game at 20 early in the fourth quarter, thinks Mariota was trying to throw to him before fumbling and said the quarterback might be taking too much of the blame for the teams offensive struggles.He only plays one position, Walker said. We all go to do our part.With the loss, the Titans missed a chance yet at their longest winning streak since 2011. They wrap up a three-game home stand Thursday night hosting Jacksonville and still searching for both ball security and offensive consistency with the second-year quarterback.With what happened (Sunday), guys are hungry to get back on the field, Mariota said. Its an opportunity to get back on track and get rolling again.---Online:AP NFL website: www.pro32.ap.org and AP NFL Twitter feed: https://twitter.com/AP-NFLFollow Teresa M. Walker at www.twitter.com/teresamwalkerSneakers Clearance Sale Canada . -- Tony Stewart is 20 pounds lighter and has a titanium rod in his surgically repaired right leg. Sneakers Canada Sale . 10 VCU 85-67 on Thursday night at the Puerto Rico Tip-Off. The Seminoles (4-0) have scored at least 80 points in each of their games. http://www.sneakersclearancecanada.com/ . - Blake Griffin had 30 points and 12 rebounds, J. Wholesale Sneakers Canada . Scott Kazmir allowed four hits in seven shutout innings, Michael Brantley hit a two-run homer in a three-run first inning and the Indians maintained their hold on an AL wild-card spot with a 4-1 win over the Houston Astros on Saturday night. Buy Sneakers Online Canada .C. -- Chris Thorburn thinks one of the reasons the Winnipeg Jets have been successful under new coach Paul Maurice is that theyre playing together as a team. LAS VEGAS -- Chris Weidman sent a shock wave through mixed martial arts, stopping Anderson Silva in the second round of the main event at UFC 162 to become the new middleweight champion on Saturday night. Silva talked, taunted and dared Weidman to engage him. When the champion lowered his hands early in the second round, Weidman caught him with a short left that sent the MMA star to the mat. Weidman pounced and landed a few more shots that forced referee Herb Dean to stop the fight at 1:18. "I felt destined for this," Weidman said. "It was far-fetched, but I imagined it so many times before in my head." The win put an end to Silvas nearly seven-year reign atop the UFC middleweight division and his 17-fight win streak. "I worked for this fight, Chris Weidman is the best now. 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