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BARCELONA, Spain -- Lionel Messi netted two goals within 15 minutes of coming on as a substitute to give Barcelona a 4-2 comeback win over Real Betis on Sunday and push his team to the brink of the Spanish league title. After his teammates had rallied back twice to level at 2-2, Messi went on in the 56th and four minutes later curled in a free kick to extend his record scoring streak to 21 straight league appearances. The Argentina forward struck again in the 71st by polishing off a superb passing combination with Andres Iniesta and fellow goalscorer Alexis Sanchez to reach the 60-goal mark in all competitions for the second straight season. "We know Messi is the best," Barcelona defender Gerard Pique said. "We know every time he comes on he will give us something." Barcelona leads by 11 points with four rounds to go and would clinch its 22nd domestic crown if defending champion Real Madrid drops points against Malaga on Wednesday. Messi has been hampered for the past month by a right hamstring injury. Since hurting his leg on April 2, the four-time world player of the year has missed four games-- including Wednesdays stinging 3-0 loss to Bayern Munich that sealed its exit from the Champions League-- and come off the bench in two more before Sundays match. Like last weeks game at Athletic Bilbao, Messi looked fit enough as he again tilted the match in Barcelonas favour. "Against Messi, you cant do anything," said Betis coach Pepe Mel, whose team remained in seventh place. "At San Mames he ran through opposing players like they were cones. And here, the first ball he touches he puts it right inside the corner of the goalframe. It was like it had been scripted. It was suddenly a big party and went down from there." Messis double gave took his league-leading goal tally to 46 for the season, and kept him on pace to beat his own record of 50 from the last campaign. Elsewhere on Sunday, Real Zaragoza beat Rayo Vallecano 3-0 to escape the relegation zone, while Mallorca remained in last place after drawing 1-1 with Levante. Sevilla, meanwhile, rolled to a 3-0 victory over Espanyol to move into eighth place and stay in the hunt for a Europa League berth. Barcelona showed signs of still feeling the effects of its midweek defeat to Bayern that completed its 7-0 dismantling of the Catalan side over their two-leg semifinal. Barcelona was sluggish at the start and in the second minute its defence was slow to react to an apparently routine high ball that bounced through to Dorlan Pabon, who expertly slotted it beyond goalkeeper Jose Pinto, playing for the injured Victor Valdes. Whistles of frustration were immediately heard from the demanding Camp Nou crowd, and they combined with the drizzling rain to further damper the hosts spirits just when they should have been trying to take a step toward the league title. Barcelona was quick to react, and with Messi on the bench, it fell to playmaker Iniesta to unlock Betis defence in the ninth when he picked out Alexis at the far post to nod in his cross. Barcelona pressed for a second goal with David Villa squandering two good chances before Cristian Tello hit the crossbar. But it was Betis that went ahead again-- this time against the run of play-- with Ruben Perezs unstoppable long strike from well outside the area that Pinto had no chance to keep out two minutes before halftime. "Football was a little cruel with us in the first half," Pique said. "We created a lot of scoring opportunities while they scored on the two chances they had, but then it was kind to us in the second half. "We are close to the title. The sooner it comes, the better." Messi started to warm up at the start of the second half to the relief of the home fans who cheered his presence on the sideline. Seconds before coming off for Messi, Villa made up for his earlier misses by knocking Dani Alves cross under goalie Adrian San Miguel with a header after Betis defence has left him unmarked in the box. Messi then took over in his 20th multi-goal game of the season. He had touched the ball just once when he scored an exquisite free kick, bending a left-footed shot just inside the near corner of the goalframe that San Miguel did well to touch but couldnt turn away. Messi almost hit with another free kick in the 69th, with the ball landing on the corner of the goalframe. But his second goal soon came when Messi linked up with Iniesta, who flicked on a no-look pass to play Alexis free in the area. The Chile forward then unselfishly crossed for Messi to tap in and complete the kind of beautiful move that Barcelona is known for and few other teams are capable of performing.Wayne Gretzky Jersey . Louis Cardinals. Victorino is batting sixth and playing right field after missing two games because of back tightness. Jakob Chychrun Jersey . -- Josh Sterk scored once and set up two more as the Oshawa Generals edged the visiting Belleville Bulls 3-2 on Friday in Ontario Hockey League action. http://www.coyotesteamstoreonline.com/authentic-darcy-kuemper-coyotes-jersey/ . Pierce was ejected in the third quarter of Indianas 103-86 win Monday. George Hill stole a bad pass and was going in for a layup, and Pierce hustled back and appeared to be trying to wrap him up. Thomas Steen Jersey . Francis told several hundred members of the European Olympic Committees that when sport "is considered only in economic terms and consequently for victory at every cost . Teppo Numminen Jersey .Y. -- Marcell Dareus and the Buffalo Bills defence made life miserable for Super Bowl MVP Joe Flacco.James Wade and Dave Chisnall are the major players who could suffer in the Grand Slam of Darts group stage, says Wayne Mardle.They have been drawn alongside James Wilson, No 36 on the PDCs Order of Merit, and Jamie Hughes, the BDOs No 4, in Group G.Sky Sports Mardle believes that represents the most competitive foursome - even more so than Group A which tees up the mouth-watering meeting between Michael van Gerwen and Martin Wolfie Adams. I dont think Hughes or Wilson would beat Wade or Chisnall over the best-of-19 legs, but over the best-of-nine? Yes. I really do. Wayne Mardle Live Grand Slam of Darts November 12, 2016, 7:30pm Live on Get Sky Sports Get a Sky Sports pass Dont rule out Jamie Hughes, hes a brilliant player, Mardle told Sky Sports.dddddddddddd I dont think Hughes or Wilson would beat Wade or Chisnall over the best-of-19 legs, but over the best-of-nine? Yes. I really do, I think they can beat anyone over nine legs.Hughes was one of the very favoured players in this years BDO world championship. He wins ranking events on a regular basis.Wilson, after joining the PDC from the BDO, its taken two years to find his feet. But now hes playing as well as we know he can. Hes a brilliant player, and probably more dangerous over a short format rather than long. Hes quite consistent, but over a long format, the big guys would out-play him.Click here to see the order of play.Click here to see the full first-round draw.The Grand Slam of Darts is live on Sky Sports between November 12-20.Also See:MVG: The greatest or the best?Grand Slam order of playSky Bets darts oddsOn Sky TV ' ' '